Military Medical Research (2024)

Table of Contents
Gastroenteropancreatic neuroendocrine neoplasms: current development, challenges, and clinical perspectives Advances in the isolation, cultivation, and identification of gut microbes Advancing skeletal health and disease research with single-cell RNA sequencing Mitochondrial quality control in human health and disease Spatiotemporal multi-omics: exploring molecular landscapes in aging and regenerative medicine P. gingivalis in oral-prostate axis exacerbates benign prostatic hyperplasia via IL-6/IL-6R pathway Biomaterials science and surface engineering strategies for dental peri-implantitis management D-mannose alleviates intervertebral disc degeneration through glutamine metabolism Neuronal Panx1 drives peripheral sensitization in experimental plantar inflammatory pain N-terminal pro-brain natriuretic peptide – a significant biomarker of disease development and adverse prognosis in patients with exertional heat stroke CRISPR/Cas9 nickase mediated signal amplification integrating with the trans-cleavage activity of Cas12a for highly selective and sensitive detection of single base mutations Exosomal mediators in sepsis and inflammatory organ injury: unraveling the role of exosomes in intercellular crosstalk and organ dysfunction Cellular therapeutics and immunotherapies in wound healing – on the pulse of time? Interferon-α stimulates DExH-box helicase 58 to prevent hepatocyte ferroptosis The implications of single-cell RNA-seq analysis in prostate cancer: unraveling tumor heterogeneity, therapeutic implications and pathways towards personalized therapy FOXO1 reshapes neutrophils to aggravate acute brain damage and promote late depression after traumatic brain injury Immune cells: potential carriers or agents for drug delivery to the central nervous system Heart-brain axis: low blood pressure during off-pump CABG surgery is associated with postoperative heart failure Endophilin A2 controls touch and mechanical allodynia via kinesin-mediated Piezo2 trafficking Targeting vulnerable microcircuits in the ventral hippocampus of male transgenic mice to rescue Alzheimer-like social memory loss Emerging roles of ADP-dependent gluco*kinase in prostate cancer CT whole lung radiomic nomogram: a potential biomarker for lung function evaluation and identification of COPD Biomaterial-based mechanical regulation facilitates scarless wound healing with functional skin appendage regeneration ADP-dependent gluco*kinase: the ancient, archaeal key to prostate cancer Deciphering the molecular interplay and tumorigenesis in hepatocellular carcinoma through insights into FBXL6 and KRASG12D In situ genetic engineering of host T-cells based on acellular scaffold strategy: a big but also small step for solid tumor immunotherapy Alleviating mitochondrial dysfunction in diabetic cardiomyopathy through the Adipsin and Irak2 pathways Nickel’s carcinogenicity: the need of more studies to progress Antimicrobial resistance crisis: could artificial intelligence be the solution? Monitoring of urinary iodine concentration in naval pilots: should iodine be supplemented or limited at coastal stations? Gulf War illness with or without post-traumatic stress disorder: differential symptoms and immune responses GPR65 as a potential novel therapeutic target for the treatment of hepatic fibrosis Acellular scaffold-based approach for in situ genetic engineering of host T-cells in solid tumor immunotherapy Interleukin-1 receptor associated kinase 2 is a functional downstream regulator of complement factor D that controls mitochondrial fitness in diabetic cardiomyopathy Disentangling the effects of PTSD from Gulf War Illness in male veterans via a systems-wide analysis of immune cell, cytokine, and symptom measures Elevated FBXL6 activates both wild-type KRAS and mutant KRASG12D and drives HCC tumorigenesis via the ERK/mTOR/PRELID2/ROS axis in mice The applied principles of EEG analysis methods in neuroscience and clinical neurology Apoptosis-resistant megakaryocytes produce large and hyperreactive platelets in response to radiation injury Pre-hospital application of REBOA for life-threatening hemorrhage ADP-dependent gluco*kinase controls metabolic fitness in prostate cancer progression Adipsin inhibits Irak2 mitochondrial translocation and improves fatty acid β-oxidation to alleviate diabetic cardiomyopathy Targeting NR1D1 in organ injury: challenges and prospects BET inhibitors potentiate melanoma ferroptosis and immunotherapy through AKR1C2 inhibition Targeting the epigenome to reinvigorate T cells for cancer immunotherapy Mesenchymal stem cell-derived extracellular vesicles in skin wound healing: the risk of senescent drift induction in secretome-based therapeutics From immunology to artificial intelligence: revolutionizing latent tuberculosis infection diagnosis with machine learning Human urinary cells for functional wound healing with sweat gland restoration Targeting GPR65 alleviates hepatic inflammation and fibrosis by suppressing the JNK and NF-κB pathways Cognitive function among military veterans with STEM occupations Insights into the underlying pathogenesis and therapeutic potential of endoplasmic reticulum stress in degenerative musculoskeletal diseases References
  • Gastroenteropancreatic neuroendocrine neoplasms: current development, challenges, and clinical perspectives

    Neuroendocrine neoplasms (NENs) are highly heterogeneous and potentially malignant tumors arising from secretory cells of the neuroendocrine system. Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) a...

    Authors: Xian-Bin Zhang, Yi-Bao Fan, Rui Jing, Mikiyas Amare Getu, Wan-Ying Chen, Wei Zhang, Hong-Xia Dong, Tikam Chand Dakal, Akhtar Hayat, Hua-Jun Cai, Milad Ashrafizadeh, A. M. Abd El-Aty, Ahmet Hacimuftuoglu, Peng Liu, Tian-Feng Li, Gautam Sethi…

    Citation: Military Medical Research 2024 11:35

    Content type: Review Published on: 4 June 2024

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  • Advances in the isolation, cultivation, and identification of gut microbes

    The gut microbiome is closely associated with human health and the development of diseases. Isolating, characterizing, and identifying gut microbes are crucial for research on the gut microbiome and essential ...

    Authors: Meng-Qi Xu, Fei Pan, Li-Hua Peng and Yun-Sheng Yang

    Citation: Military Medical Research 2024 11:34

    Content type: Review Published on: 3 June 2024

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  • Advancing skeletal health and disease research with single-cell RNA sequencing

    Orthopedic conditions have emerged as global health concerns, impacting approximately 1.7billion individuals worldwide. However, the limited understanding of the underlying pathological processes at the cellu...

    Authors: Peng Lin, Yi-Bo Gan, Jian He, Si-En Lin, Jian-Kun Xu, Liang Chang, Li-Ming Zhao, Jun Zhu, Liang Zhang, Sha Huang, Ou Hu, Ying-Bo Wang, Huai-Jian Jin, Yang-Yang Li, Pu-Lin Yan, Lin Chen…

    Citation: Military Medical Research 2024 11:33

    Content type: Review Published on: 30 May 2024

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  • Mitochondrial quality control in human health and disease

    Mitochondria, the most crucial energy-generating organelles in eukaryotic cells, play a pivotal role in regulating energy metabolism. However, their significance extends beyond this, as they are also indispens...

    Authors: Bo-Hao Liu, Chen-Zhen Xu, Yi Liu, Zi-Long Lu, Ting-Lv Fu, Guo-Rui Li, Yu Deng, Guo-Qing Luo, Song Ding, Ning Li and Qing Geng

    Citation: Military Medical Research 2024 11:32

    Content type: Review Published on: 29 May 2024

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  • Spatiotemporal multi-omics: exploring molecular landscapes in aging and regenerative medicine

    Aging and regeneration represent complex biological phenomena that have long captivated the scientific community. To fully comprehend these processes, it is essential to investigate molecular dynamics through ...

    Authors: Liu-Xi Chu, Wen-Jia Wang, Xin-Pei Gu, Ping Wu, Chen Gao, Quan Zhang, Jia Wu, Da-Wei Jiang, Jun-Qing Huang, Xin-Wang Ying, Jia-Men Shen, Yi Jiang, Li-Hua Luo, Jun-Peng Xu, Yi-Bo Ying, Hao-Man Chen…

    Citation: Military Medical Research 2024 11:31

    Content type: Review Published on: 27 May 2024

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  • P. gingivalis in oral-prostate axis exacerbates benign prostatic hyperplasia via IL-6/IL-6R pathway

    Benign prostatic hyperplasia (BPH) is the most common disease in elderly men. There is increasing evidence that periodontitis increases the risk of BPH, but the specific mechanism remains unclear. This study a...

    Authors: Shuang-Ying Wang, Yi Cai, Xiao Hu, Fei Li, Xin-Hang Qian, Ling-Yun Xia, Bo Gao, Lan Wu, Wen-Zhong Xie, Jia-Min Gu, Tong Deng, Cong Zhu, Hai-Chang Jia, Wan-Qi Peng, Jiao Huang, Cheng Fang…

    Citation: Military Medical Research 2024 11:30

    Content type: Research Published on: 20 May 2024

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  • Biomaterials science and surface engineering strategies for dental peri-implantitis management

    Peri-implantitis is a bacterial infection that causes soft tissue inflammatory lesions and alveolar bone resorption, ultimately resulting in implant failure. Dental implants for clinical use barely have antiba...

    Authors: Ya-Meng Yu, Yu-Pu Lu, Ting Zhang, Yu-Feng Zheng, Yun-Song Liu and Dan-Dan Xia

    Citation: Military Medical Research 2024 11:29

    Content type: Review Published on: 13 May 2024

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  • D-mannose alleviates intervertebral disc degeneration through glutamine metabolism

    Intervertebral disc degeneration (IVDD) is a multifaceted condition characterized by heterogeneity, wherein the balance between catabolism and anabolism in the extracellular matrix of nucleus pulposus (NP) cel...

    Authors: Zheng-Lin Dong, Xin Jiao, Zeng-Guang Wang, Kai Yuan, Yi-Qi Yang, Yao Wang, Yun-Tao Li, Tian-Chang Wang, Tian-You Kan, Jian Wang and Hai-Rong Tao

    Citation: Military Medical Research 2024 11:28

    Content type: Research Published on: 6 May 2024

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  • Neuronal Panx1 drives peripheral sensitization in experimental plantar inflammatory pain

    The channel-forming protein Pannexin1 (Panx1) has been implicated in both human studies and animal models of chronic pain, but the underlying mechanisms remain incompletely understood.

    Authors: Qu Xing, Antonio Cibelli, Greta Luyuan Yang, Preeti Dohare, Qing-Hua Li, Eliana Scemes, Fang-Xia Guan and David C. Spray

    Citation: Military Medical Research 2024 11:27

    Content type: Research Published on: 29 April 2024

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  • N-terminal pro-brain natriuretic peptide – a significant biomarker of disease development and adverse prognosis in patients with exertional heat stroke

    Authors: Long Feng, Jian-Yuan Yin, Yao-Hong Liu, Pei Zhang, Ya-Li Zhao, Qing Song, Ping Ping and Shi-Hui Fu

    Citation: Military Medical Research 2024 11:26

    Content type: Letter to the Editor Published on: 23 April 2024

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  • CRISPR/Cas9 nickase mediated signal amplification integrating with the trans-cleavage activity of Cas12a for highly selective and sensitive detection of single base mutations

    Authors: Xiao-Wen Fan, Zi-Fan Gao, Dong-Dong Ling, De-Hui Wang, Ying Cui, Hui-Qun Du, Chun-Lin Li and Xing Zhou

    Citation: Military Medical Research 2024 11:25

    Content type: Letter to the Editor Published on: 23 April 2024

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  • Exosomal mediators in sepsis and inflammatory organ injury: unraveling the role of exosomes in intercellular crosstalk and organ dysfunction

    Sepsis, a severe systemic inflammatory response to infection, remains a leading cause of morbidity and mortality worldwide. Exosomes, as mediators of intercellular communication, play a pivotal role in the pat...

    Authors: Ting Gong, You-Tan Liu and Jie Fan

    Citation: Military Medical Research 2024 11:24

    Content type: Review Published on: 22 April 2024

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  • Cellular therapeutics and immunotherapies in wound healing – on the pulse of time?

    Chronic, non-healing wounds represent a significant challenge for healthcare systems worldwide, often requiring significant human and financial resources. Chronic wounds arise from the complex interplay of und...

    Authors: Lioba Huelsboemer, Leonard Knoedler, Alejandro Kochen, Catherine T. Yu, Helia Hosseini, Katharina S. Hollmann, Ashley E. Choi, Viola A. Stögner, Samuel Knoedler, Henry C. Hsia, Bohdan Pomahac and Martin Kauke-Navarro

    Citation: Military Medical Research 2024 11:23

    Content type: Review Published on: 18 April 2024

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  • Interferon-α stimulates DExH-box helicase 58 to prevent hepatocyte ferroptosis

    Liver ischemia/reperfusion (I/R) injury is usually caused by hepatic inflow occlusion during liver surgery, and is frequently observed during war wounds and trauma. Hepatocyte ferroptosis plays a critical role...

    Authors: Kai-Wei Jia, Ren-Qi Yao, Yi-Wen Fan, Ding-Ji Zhang, Ye Zhou, Min-Jun Wang, Li-Yuan Zhang, Yue Dong, Zhi-Xuan Li, Su-Yuan Wang, Mu Wang, Yun-Hui Li, Lu-Xin Zhang, Ting Lei, Liang-Chen Gui, Shan Lu…

    Citation: Military Medical Research 2024 11:22

    Content type: Research Published on: 15 April 2024

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  • The implications of single-cell RNA-seq analysis in prostate cancer: unraveling tumor heterogeneity, therapeutic implications and pathways towards personalized therapy

    In recent years, advancements in single-cell and spatial transcriptomics, which are highly regarded developments in the current era, particularly the emerging integration of single-cell and spatiotemporal tran...

    Authors: De-Chao Feng, Wei-Zhen Zhu, Jie Wang, Deng-Xiong Li, Xu Shi, Qiao Xiong, Jia You, Ping Han, Shi Qiu, Qiang Wei and Lu Yang

    Citation: Military Medical Research 2024 11:21

    Content type: Review Published on: 11 April 2024

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  • FOXO1 reshapes neutrophils to aggravate acute brain damage and promote late depression after traumatic brain injury

    Neutrophils are traditionally viewed as first responders but have a short onset of action in response to traumatic brain injury (TBI). However, the heterogeneity, multifunctionality, and time-dependent modulat...

    Authors: Mi Zhou, Yang-Wu-Yue Liu, Yu-Hang He, Jing-Yu Zhang, Hao Guo, Hao Wang, Jia-Kui Ren, Yi-Xun Su, Teng Yang, Jia-Bo Li, Wen-Hui He, Peng-Jiao Ma, Man-Tian Mi and Shuang-Shuang Dai

    Citation: Military Medical Research 2024 11:20

    Content type: Research Published on: 31 March 2024

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  • Immune cells: potential carriers or agents for drug delivery to the central nervous system

    Drug delivery systems (DDS) have recently emerged as a promising approach for the unique advantages of drug protection and targeted delivery. However, the access of nanoparticles/drugs to the central nervous s...

    Authors: Shan-Shan Zhang, Ruo-Qi Li, Zhong Chen, Xiao-Ying Wang, Aaron S. Dumont and Xiang Fan

    Citation: Military Medical Research 2024 11:19

    Content type: Review Published on: 29 March 2024

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  • Heart-brain axis: low blood pressure during off-pump CABG surgery is associated with postoperative heart failure

    Authors: Xiu-Yun Liu, Jing-Jing Mu, Jian-Ge Han, Mei-Jun Pang, Kuo Zhang, Wen-Qian Zhai, Nan Su, Guang-Jian Ni, Zhi-Gang Guo and Dong Ming

    Citation: Military Medical Research 2024 11:18

    Content type: Letter to the Editor Published on: 20 March 2024

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  • Endophilin A2 controls touch and mechanical allodynia via kinesin-mediated Piezo2 trafficking

    Tactile and mechanical pain are crucial to our interaction with the environment, yet the underpinning molecular mechanism is still elusive. Endophilin A2 (EndoA2) is an evolutionarily conserved protein that is...

    Authors: Man-Xiu Xie, Ren-Chun Lai, Yi-Bin Xiao, Xi Zhang, Xian-Ying Cao, Xiao-Yu Tian, An-Nan Chen, Zi-Yi Chen, Yan Cao, Xiao Li and Xiao-Long Zhang

    Citation: Military Medical Research 2024 11:17

    Content type: Research Published on: 12 March 2024

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  • Targeting vulnerable microcircuits in the ventral hippocampus of male transgenic mice to rescue Alzheimer-like social memory loss

    Episodic memory loss is a prominent clinical manifestation of Alzheimer’s disease (AD), which is closely related to tau pathology and hippocampal impairment. Due to the heterogeneity of brain neurons, the spec...

    Authors: Hui-Yang Lei, Gui-Lin Pi, Ting He, Rui Xiong, Jing-Ru Lv, Jia-Le Liu, Dong-Qin Wu, Meng-Zhu Li, Kun Shi, Shi-Hong Li, Na-Na Yu, Yang Gao, Hui-Ling Yu, Lin-Yu Wei, Xin Wang, Qiu-Zhi Zhou…

    Citation: Military Medical Research 2024 11:16

    Content type: Research Published on: 11 March 2024

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  • Emerging roles of ADP-dependent gluco*kinase in prostate cancer

    Authors: Xu Zhang

    Citation: Military Medical Research 2024 11:15

    Content type: Commentary Published on: 27 February 2024

    The original article was published in Military Medical Research 2023 10:64

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  • CT whole lung radiomic nomogram: a potential biomarker for lung function evaluation and identification of COPD

    Computed tomography (CT) plays a great role in characterizing and quantifying changes in lung structure and function of chronic obstructive pulmonary disease (COPD). This study aimed to explore the performance...

    Authors: Tao-Hu Zhou, Xiu-Xiu Zhou, Jiong Ni, Yan-Qing Ma, Fang-Yi Xu, Bing Fan, Yu Guan, Xin-Ang Jiang, Xiao-Qing Lin, Jie Li, Yi Xia, Xiang Wang, Yun Wang, Wen-Jun Huang, Wen-Ting Tu, Peng Dong…

    Citation: Military Medical Research 2024 11:14

    Content type: Research Published on: 20 February 2024

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  • Biomaterial-based mechanical regulation facilitates scarless wound healing with functional skin appendage regeneration

    Scar formation resulting from burns or severe trauma can significantly compromise the structural integrity of skin and lead to permanent loss of skin appendages, ultimately impairing its normal physiological f...

    Authors: Ying-Ying Li, Shuai-Fei Ji, Xiao-Bing Fu, Yu-Feng Jiang and Xiao-Yan Sun

    Citation: Military Medical Research 2024 11:13

    Content type: Review Published on: 18 February 2024

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  • ADP-dependent gluco*kinase: the ancient, archaeal key to prostate cancer

    Authors: Marcin M. Kamiński

    Citation: Military Medical Research 2024 11:10

    Content type: Commentary Published on: 12 February 2024

    The original article was published in Military Medical Research 2023 10:64

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  • Deciphering the molecular interplay and tumorigenesis in hepatocellular carcinoma through insights into FBXL6 and KRASG12D

    Authors: Qiang Cai and Quazi T. H. Shubhra

    Citation: Military Medical Research 2024 11:9

    Content type: Commentary Published on: 8 February 2024

    The original article was published in Military Medical Research 2023 10:68

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  • In situ genetic engineering of host T-cells based on acellular scaffold strategy: a big but also small step for solid tumor immunotherapy

    Authors: Shu-Yan Han, Zi-Xuan Zhao and Jun Wu

    Citation: Military Medical Research 2024 11:12

    Content type: Commentary Published on: 3 February 2024

    The original article was published in Military Medical Research 2024 11:3

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  • Alleviating mitochondrial dysfunction in diabetic cardiomyopathy through the Adipsin and Irak2 pathways

    Authors: Mabel L. Cummins, Grace Delmonte, Skylar Wechsler and Joseph J. Schlesinger

    Citation: Military Medical Research 2024 11:11

    Content type: Commentary Published on: 1 February 2024

    The original article was published in Military Medical Research 2023 10:63

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  • Nickel’s carcinogenicity: the need of more studies to progress

    Authors: Consolato M. Sergi

    Citation: Military Medical Research 2024 11:8

    Content type: Letter to the Editor Published on: 25 January 2024

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  • Antimicrobial resistance crisis: could artificial intelligence be the solution?

    Antimicrobial resistance is a global public health threat, and the World Health Organization (WHO) has announced a priority list of the most threatening pathogens against which novel antibiotics need to be dev...

    Authors: Guang-Yu Liu, Dan Yu, Mei-Mei Fan, Xu Zhang, Ze-Yu Jin, Christoph Tang and Xiao-Fen Liu

    Citation: Military Medical Research 2024 11:7

    Content type: Review Published on: 23 January 2024

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  • Monitoring of urinary iodine concentration in naval pilots: should iodine be supplemented or limited at coastal stations?

    Authors: Jia Zeng, Qi Li, Xiang Lu, Dan-Dan Liu, Rong-Guan Jiao, Yan-Qing Jiang, Yan-Bing Liu, Wan-Qing Xu, Jun Ma and Guo-Li Gu

    Citation: Military Medical Research 2024 11:6

    Content type: Letter to the Editor Published on: 22 January 2024

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  • Gulf War illness with or without post-traumatic stress disorder: differential symptoms and immune responses

    Authors: Faith Nguyen and Ashok K. Shetty

    Citation: Military Medical Research 2024 11:5

    Content type: Commentary Published on: 12 January 2024

    The original article was published in Military Medical Research 2024 11:2

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  • GPR65 as a potential novel therapeutic target for the treatment of hepatic fibrosis

    Authors: Leila Gobejishvili

    Citation: Military Medical Research 2024 11:4

    Content type: Commentary Published on: 8 January 2024

    The original article was published in Military Medical Research 2023 10:56

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  • Acellular scaffold-based approach for in situ genetic engineering of host T-cells in solid tumor immunotherapy

    Targeted T-cell therapy has emerged as a promising strategy for the treatment of hematological malignancies. However, its application to solid tumors presents significant challenges due to the limited accessib...

    Authors: Hiren Y. Dandia, Mamatha M. Pillai, Deepak Sharma, Meghna Suvarna, Neha Dalal, Ayush Madhok, Arvind Ingle, Shubhada V. Chiplunkar, Sanjeev Galande and Prakriti Tayalia

    Citation: Military Medical Research 2024 11:3

    Content type: Research Published on: 4 January 2024

    The Commentary to this article has been published in Military Medical Research 2024 11:12

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  • Interleukin-1 receptor associated kinase 2 is a functional downstream regulator of complement factor D that controls mitochondrial fitness in diabetic cardiomyopathy

    Authors: Stanislovas S. Jankauskas, Fahimeh Varzideh, Pasquale Mone, Urna Kansakar, Francesco Di Lorenzo, Angela Lombardi and Gaetano Santulli

    Citation: Military Medical Research 2024 11:1

    Content type: Commentary Published on: 3 January 2024

    The original article was published in Military Medical Research 2023 10:63

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  • Disentangling the effects of PTSD from Gulf War Illness in male veterans via a systems-wide analysis of immune cell, cytokine, and symptom measures

    One-third of veterans returning from the 1990–1991 Gulf War reported a myriad of symptoms including cognitive dysfunction, skin rashes, musculoskeletal discomfort, and fatigue. This symptom cluster is now refe...

    Authors: Esha Sultana, Nandan Shastry, Rishabh Kasarla, Jacob Hardy, Fanny Collado, Kristina Aenlle, Maria Abreu, Emily Sisson, Kimberly Sullivan, Nancy Klimas and Travis J. A. Craddock

    Citation: Military Medical Research 2024 11:2

    Content type: Research Published on: 2 January 2024

    The Commentary to this article has been published in Military Medical Research 2024 11:5

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  • Elevated FBXL6 activates both wild-type KRAS and mutant KRASG12D and drives HCC tumorigenesis via the ERK/mTOR/PRELID2/ROS axis in mice

    Kirsten rat sarcoma (KRAS) and mutant KRASG12D have been implicated in human cancers, but it remains unclear whether their activation requires ubiquitination. This study aimed to investigate whether and how F-box...

    Authors: Hao-Jun Xiong, Hong-Qiang Yu, Jie Zhang, Lei Fang, Di Wu, Xiao-Tong Lin and Chuan-Ming Xie

    Citation: Military Medical Research 2023 10:68

    Content type: Research Published on: 20 December 2023

    The Commentary to this article has been published in Military Medical Research 2024 11:9

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  • The applied principles of EEG analysis methods in neuroscience and clinical neurology

    Electroencephalography (EEG) is a non-invasive measurement method for brain activity. Due to its safety, high resolution, and hypersensitivity to dynamic changes in brain neural signals, EEG has aroused much i...

    Authors: Hao Zhang, Qing-Qi Zhou, He Chen, Xiao-Qing Hu, Wei-Guang Li, Yang Bai, Jun-Xia Han, Yao Wang, Zhen-Hu Liang, Dan Chen, Feng-Yu Cong, Jia-Qing Yan and Xiao-Li Li

    Citation: Military Medical Research 2023 10:67

    Content type: Review Published on: 19 December 2023

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  • Apoptosis-resistant megakaryocytes produce large and hyperreactive platelets in response to radiation injury

    The essential roles of platelets in thrombosis have been well recognized. Unexpectedly, thrombosis is prevalent during thrombocytopenia induced by cytotoxicity of biological, physical and chemical origins, whi...

    Authors: Chang-Hong Du, Yi-Ding Wu, Ke Yang, Wei-Nian Liao, Li Ran, Chao-Nan Liu, Shu-Zhen Zhang, Kuan Yu, Jun Chen, Yong Quan, Mo Chen, Ming-Qiang Shen, Hong Tang, Shi-Lei Chen, Song Wang, Jing-Hong Zhao…

    Citation: Military Medical Research 2023 10:66

    Content type: Research Published on: 19 December 2023

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  • Pre-hospital application of REBOA for life-threatening hemorrhage

    Authors: Xiao-Mei Tian, Wei Hu and Feng-Yong Liu

    Citation: Military Medical Research 2023 10:65

    Content type: Letter to the Editor Published on: 13 December 2023

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  • ADP-dependent gluco*kinase controls metabolic fitness in prostate cancer progression

    Cell metabolism plays a pivotal role in tumor progression, and targeting cancer metabolism might effectively kill cancer cells. We aimed to investigate the role of hexokinases in prostate cancer (PCa) and iden...

    Authors: Hang Xu, Yi-Fan Li, Xian-Yan-Ling Yi, Xiao-Nan Zheng, Yang Yang, Yan Wang, Da-Zhou Liao, Jia-Peng Zhang, Ping Tan, Xing-Yu Xiong, Xi Jin, Li-Na Gong, Shi Qiu, De-Hong Cao, Hong Li, Qiang Wei…

    Citation: Military Medical Research 2023 10:64

    Content type: Research Published on: 12 December 2023

    The Commentary to this article has been published in Military Medical Research 2024 11:15

    The Commentary to this article has been published in Military Medical Research 2024 11:10

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  • Adipsin inhibits Irak2 mitochondrial translocation and improves fatty acid β-oxidation to alleviate diabetic cardiomyopathy

    Diabetic cardiomyopathy (DCM) causes the myocardium to rely on fatty acid β-oxidation for energy. The accumulation of intracellular lipids and fatty acids in the myocardium usually results in lipotoxicity, whi...

    Authors: Meng-Yuan Jiang, Wan-Rong Man, Xue-Bin Zhang, Xiao-Hua Zhang, Yu Duan, Jie Lin, Yan Zhang, Yang Cao, De-Xi Wu, Xiao-Fei Shu, Lei Xin, Hao Wang, Xiao Zhang, Cong-Ye Li, Xiao-Ming Gu, Xuan Zhang…

    Citation: Military Medical Research 2023 10:63

    Content type: Research Published on: 11 December 2023

    The Commentary to this article has been published in Military Medical Research 2024 11:11

    The Commentary to this article has been published in Military Medical Research 2024 11:1

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  • Targeting NR1D1 in organ injury: challenges and prospects

    Nuclear receptor subfamily 1, group D, member 1 (NR1D1, also known as REV-ERBα) belongs to the nuclear receptor (NR) family, and is a heme-binding component of the circadian clock that consolidates circadian o...

    Authors: Zi-Yin Zhang-sun, Xue-Zeng Xu, Germaine Escames, Wang-Rui Lei, Lin Zhao, Ya-Zhe Zhou, Ye Tian, Ya-Nan Ren, Darío Acuña-Castroviejo and Yang Yang

    Citation: Military Medical Research 2023 10:62

    Content type: Review Published on: 11 December 2023

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  • BET inhibitors potentiate melanoma ferroptosis and immunotherapy through AKR1C2 inhibition

    Authors: Yu Meng, Hui-Yan Sun, Yi He, Qian Zhou, Yi-Huang Liu, Hui Su, Ming-Zhu Yin, Fu-Rong Zeng, Xiang Chen and Guang-Tong Deng

    Citation: Military Medical Research 2023 10:61

    Content type: Letter to the Editor Published on: 4 December 2023

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  • Targeting the epigenome to reinvigorate T cells for cancer immunotherapy

    Cancer immunotherapy using immune-checkpoint inhibitors (ICIs) has revolutionized the field of cancer treatment; however, ICI efficacy is constrained by progressive dysfunction of CD8+ tumor-infiltrating lymphocy...

    Authors: Dian Xiong, Lu Zhang and Zhi-Jun Sun

    Citation: Military Medical Research 2023 10:59

    Content type: Review Published on: 4 December 2023

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  • Mesenchymal stem cell-derived extracellular vesicles in skin wound healing: the risk of senescent drift induction in secretome-based therapeutics

    Authors: Anna Smirnova, Elena Yatsenko, Denis Baranovskii and Ilya Klabukov

    Citation: Military Medical Research 2023 10:60

    Content type: Commentary Published on: 30 November 2023

    The original article was published in Military Medical Research 2023 10:36

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  • From immunology to artificial intelligence: revolutionizing latent tuberculosis infection diagnosis with machine learning

    Latent tuberculosis infection (LTBI) has become a major source of active tuberculosis (ATB). Although the tuberculin skin test and interferon-gamma release assay can be used to diagnose LTBI, these methods can...

    Authors: Lin-Sheng Li, Ling Yang, Li Zhuang, Zhao-Yang Ye, Wei-Guo Zhao and Wen-Ping Gong

    Citation: Military Medical Research 2023 10:58

    Content type: Review Published on: 28 November 2023

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  • Human urinary cells for functional wound healing with sweat gland restoration

    Authors: Shuai-Fei Ji, Lai-Xian Zhou, Ying-Ying Li, Jiang-Bing Xiang, Hua-Ting Chen, Yi-Qiong Liu, Xiao-Bing Fu and Xiao-Yan Sun

    Citation: Military Medical Research 2023 10:57

    Content type: Letter to the Editor Published on: 28 November 2023

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  • Targeting GPR65 alleviates hepatic inflammation and fibrosis by suppressing the JNK and NF-κB pathways

    G-protein coupled receptors (GPCRs) are recognized as attractive targets for drug therapy. However, it remains poorly understood how GPCRs, except for a few chemokine receptors, regulate the progression of liv...

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    Content type: Research Published on: 25 November 2023

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    Content type: Letter to the Editor Published on: 20 November 2023

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    Citation: Military Medical Research 2023 10:54

    Content type: Review Published on: 9 November 2023

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  • Military Medical Research (2024)

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